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>Laboratory Research
Concentration |
Dr. Akinbamis' research laboratory is focused on integrated physiology of transgenic animal models, the role of high blood pressure on vascular function and gene expression profiles, and mechanisms of salt-sensitive hypertension. THE ROLE OF PRESSURE ON VASCULAR DYSFUNCTION High blood pressure or hypertension is a complex disorder
that results from the interplay of genetic and environmental influences.
Hypertension affects 25% of most adult populations and is an important
risk factor for death from stroke, myocardial infarction, congestive
heart failure, and renal failure. The molecular pathogenesis of the
most common forms of hypertension is poorly understood. Despite advances
in the understanding of pathophysiology of hypertension and advances
in antihypertensive therapy during the past 3 decades, the public health
burden of hypertension remains substantial, with nearly 50 million hypertensive
individuals in the United States alone. However, advances in the understanding
of vascular dysfunction and modulators of vascular homeostasis under
both physiological and pathological conditions will provide important
clues to the pathways underlying more common forms of disease and may
identify targets and pathways for new approaches to treatment. Current Research Project Funding Awards: Funding from National Institute of
Health National Heart, Lung and Blood Institute |