Gary H. Gibbons' Research Laboratory

It is recognized that the vasculature is a dynamic organ that is capable of sensing its environment and modulating its function and structure accordingly. Dr. Gibbons' research laboratory has a longstanding interest in elucidating the molecular mechanisms involved in vascular remodeling in health and disease. His laboratory has a major interest in defining the regulation of vascular cell growth and apoptosis and its role in the pathogenesis of vascular diseases such as hypertension and atherosclerosis. The laboratory is currently using DNA microarray technology and transgenic mouse models to characterize the genetic programs that regulate vascular cell fate and determine vessel function and structure.
One of the long-term goals of his research program is to utilize new genomic technologies to integrate the areas of physiologic genomics, functional genomics and human molecular genetics in the field of vascular biology and medicine. Dr. Gibbons' laboratory is interested in discovering novel mediators of vascular disease that may constitute candidate disease susceptibility genes. His laboratory is actively involved in collaborative projects designed to study the functional significance of genomic variation and the potential role of genetic variation in promoting the susceptibility to cardiovascular disease in both clinical and community-based cohorts.

Ongoing research projects include: