Kamla Dutt, Ph.D.
Professor, Department of Pathology
Morehouse School of Medicine
B.S., Panjab University, India
M.S., Panjab University
Ph.D., Panjab University
Email: duttk@msm.edu
Office Phone: (404) 752-1769
Department: (404) 752-1770
Fax: (404) 752-1108


Research Interests
  • Tissue engineering from human retinal stem cells.
  • The study of neuronal cell development, cell fate commitment and differentiation.
  • Developing permanent cell lines by immortalizing primary cultures of human retina, pigment epithelium and brain with known oncogenes.
  • These cell lines are currently being used to study both development and disease processes.
  • Studies on cell lineages/developmental plasticity and differentiation in human retina.
  • Study of the mechanisms of neuronal plasticity under altered gravity.
  • Retinal-endothelial cell co-cultures in the bioreactor: A three dimensional model for angiogenesis.
  • HIV, CMV interactions in human retinal, brain cell lines.
Extensive training in chromosomal cytology comprising karyotyping, giemsa, and QM banding of mammalian chromosomes; tissue culture of normal and tumor-derived human cell lines. Effects of anti-cancer drugs on cell cycle traverse; cytokinetic studies (alterations) in bone marrow and tumors of patients under chemotherapy. Extracellular matrices and growth of tumor cells. Tissue culture of embryonic retina and pigment epithelium. Cyclic nucleotide and steroid regulation of glutamine synthetase in chick embryo retina.
Human retinal precursors grown in the bioreactor. Note multilayered tissue formation (A-D). Note possible photoreceptors aligned at the periphery(C).

Relevant Publications

Dutt, K., Harris-Hooker, S., Ellerson, D., Layne, D., Kumar, R., and Hunt, R.  Generation of 3D retina like structures from human retinal cell line in a NASA bioreactor.  Cell Transplantation 2003; 12:717-731.

Dutt, K., Sanford, G., Harris-Hooker, S., Brako, L., Kumar, R., Sroufe, A., and Melhado, C.  Three-dimensional model of angiogenesis:  Co-culture of human retinal cells with bovine aortic endothelial cells in the NASA bioreactor.  Tissue Engineering 2003; 9:893-908.  

Ezeonu, I., Wang, M. Kumar, R., Dutt, K.  Density dependent differentiation in non-transformed human retinal cells in response to bFGF, TFGx.  DNA and Cell Biology 2003; 22:607-621.

Dutt, K., Scott, M., Wang, M., Semple, E., Sharma, G.P., and Srinivasan, A.  Establishment of a human retinal cell by transfection of SV40T antigen gene with potential to undergo neuronal differentiation.  DNA and Cell Biology 1994; 13:909-921.

Dutt, K., Scott, M., Del Monte, M., Agarwal, N., Sternberg, P., Srivastava, S.K., and Srinivasan, A.  Establishment of human pigment epithelial cell lines by oncogenes.  Oncogene 1990; 5:195-200.

Keywords

Tissue engineering, Retinitis pigmentosa, HIV, Human retina, Development, Differentiation, Retinal angiogenesis endothelial cells in the NASA bioreactor

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