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Signal
Transduction Research
Research is conducted utilizing both hindlimb suspended rats and
cell culture to investigate: 1) the effects of hindlimb suspension
(HLS) on catecholamine levels and ß2-adrenoceptor dynamics
and 2) the effects of HLS on polyamine levels in skeletal muscle
atrophy/hypertrophy. Drs. Abukhalaf, von Deutsch, and Wineski are
focusing on the mechanism(s) contributing to skeletal muscle atrophy
and protective mechanisms for free radical-induced atrophy resulting
from microgravity conditions. Drs. Russell, Abukhalaf, and von Deutsch
are investigating the effects of HLS on ß2-adrenoceptor density
and subsequent signal transduction events in various tissues.
Sandra
Harris-Hooker, Ph.D.
Gary
L. Sanford, Ph.D.
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