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Neuroscience Institute
Morehouse School of Medicine
720 Westview Drive
Atlanta, GA. 30310
Shobu Namura, Ph.D. 

 

Selected Publications

Inoue H, Jiang X-F, Katayama T, Osada S, Umesono K, Namura S. Resveratrol and fenofibrate require PPAR a expression to limit brain infarct resulting from permanent focal ischemia in mice. Neurosci. Lett. 2003;352:203 – 206.

Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl. Acad. Sci. USA 2001; 98:11569–11574 .

Takami S, Minami M, Nagata I, Namura S, Satoh M. Chemokine receptor antagonist peptide, viral MIP-II, protects brain against focal cerebral ischemia in mice. J. Cereb. Blood Flow and Metab. 2001; 21:1430–1435.

Jiang X-F, Namura S, Nagata I. Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice. Neurosci. Lett. 2001; 305:41–44.

Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci. Lett. 2000; 288:163–166

Kang S-J, Wang S, Hara H, Peterson EP, Srinivasan A, Amin-Hanjani S, Namura S, Tomaselli K.J. Thornberry NA, Moskowitz MA, Yuan J. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol. 2000; 149:613–622.

Alessandrini A*, Namura S*, Moskowitz MA, Bonventre JV (* equally contributed). MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc. Natl. Acad. Sci. USA 1999; 96:12866–12869.

Namura S, Zhu J, Fink K, Endres M, Tomaselli KJ, Srinivasan A, Yuan J, Moskowitz MA. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 1998; 18:3659–3668.

Endres M, Namura S, Shimizu-Sasamata M, Waeber C, Zhang L, Gomez-Isla T, Hyman BT, Moskowitz MA. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J. Cereb. Blood Flow Metab. 1998; 18:238–247.

Endres M, Wang Z-Q, Namura S, Waeber C, Moskowitz MA. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J. Cereb. Blood Flow Metab. 1997; 17: 1143–1151.