Felix O. Aikhionbare, Ph.D.
Professor
Medicine
Location: MEB 324
Phone: 404-752-1065
E-mail: faikhionbare@msm.edu
Education
GRADUATE:The University of Nebraska
Degree: Doctor of Philosophy
Jackson State University
Degree: Master of Science
UNDERGRADUATE:
Jackson State University
Degree: Bachelor of Science
Research Interests
My laboratory is dedicated to the molecular analysis of human ovarian and colorectal cancer. My overall goal is to identify differences between normal surrounding and cancerous ovarian and colorectal tissues, evaluate the consequences of these differences, and link this information to improve the clinical management of ovarian and colorectal cancer patients. Ongoing work is focused on the role of the mitochondrial genome alterations as modifier ‘genes’ in the progressive stages and dissecting the molecular basis of intra-tumor heterogeneity in ovarian and colorectal carcinoma. Other research project involved the evaluation of HLA-G gene mutations associated with prenatal transmission of HIV-1.Clinical Interests
Cancer BiologyHost-HIV 1 pathogenesis
Specialties
Molecular GeneticsPublications
Lu H, Zhao Q, Jiang H, Zhu T, Xia P, Seffens W, Aikhionbare F, Wang D, Dou Z, Yao X. Characterization of ring-like f-actin structure as a mechanical
partner for spindle positioning in mitosis. PLoS One. 2014 Oct 9;9(10):e102547. doi: 10.1371/journal.pone.0102547. eCollection 2014. PMID:
25299690
Liu X, Song Z, Huo Y, Zhang J, Zhu T, Wang J, Zhao X,Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y, Yao X. Chromatin Protein HP1α Interacts with
the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of
the Chromosomal Passenger Complex. J Biol Chem. 2014 Jul 25;289(30):20638-20649. Epub 2014 Jun 10. PMID: 24917673
Zhu T, Dou Z, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang
Z, Aikhionbare F, Fu C, Ding X, Yao X. Phosphorylation of microtubule-binding protein Hec1 by mitotic
kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore. J Biol Chem. 2013 Dec 13;288(50):36149-59. doi: 10.1074/jbc.M113.507970. Epub 2013 Nov 1. PMID:
24187132
Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X. ACAP4 protein
cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin
β1 recycling in cell migration. J Biol Chem. 2011 Dec 23;286(51):43735-47. doi: 10.1074/jbc.M111.278770. Epub 2011 Oct 25. PMID:
22027826
Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, Zhou T, Xiang H, Gao F, Yu X, Liao J,
Ward T, Xia P, Emenari C, Ding X, Thompson W, Ma K, Zhu J, Aikhionbare F, Dou K, Cheng SY, Yao X. Rho kinase phosphorylation promotes ezrin-mediated metastasis
in hepatocellular carcinoma. Cancer Res. 2011 Mar 1;71(5):1721-9. doi: 10.1158/0008-5472.CAN-09-4683. PMID: 21363921
Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C,Aikhionbare F, Fang G, Ding X, Yao X. PLK1 phosphorylates mitotic centromere-associated kinesin
and promotes its depolymerase activity. J Biol Chem. 2011 Jan 28;286(4):3033-46. doi: 10.1074/jbc.M110.165340. Epub 2010 Nov 15. PMID:
21078677
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