Barney Graham, MD

Barney S. Graham, MD, PhD 

Founding Director of the David Satcher Global Health Equity Institute

Professor of Medicine and Microbiology, Biochemistry, & Immunology

Microbiology, Biochemistry & Immunology
E-mail: bgraham@msm.edu

Education

POSTGRADUATE:
Vanderbilt University School of Medicine
Clinical Fellowship: Infectious Diseases
Chief Residencies: Nashville General Hospital & Vanderbilt University Hospital. 

Vanderbilt University School of Medicine
Residency: Resident, Internal Medicine

Vanderbilt University School of Medicine
Internship: Internal Medicine

GRADUATE:
Vanderbilt University
Degree: Doctor of Philosophy

University of Kansas, School of Medicine
Degree: Doctor of Medicine

UNDERGRADUATE:
Rice University
Degree: Bachelor of Arts, Magna Cum Laude, Phi Beta Kappa

Board Certification

  • Board Certification: American Board of Internal Medicine, 1983, #94606
  • American Board of Infectious Diseases,1986, #94606

Publications

Original Research

  • Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M. Quadrivalent influenza nanoparticle vaccines induce broad protection. Nature 2021 Mar 24; doi: 10.1038/s41586-021-03365-x.
  • Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahi K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 2020 Aug 5; doi: 10.1038/s41586-020-2622-0.
  • Corbett KS, Flynn B, Foulds KE, Francica JR, Boyoglu-Barnum S, Werner AP, Flach B, O'Connell S, Bock KW, Minai M, Nagata BM, Andersen H, Martinez DR, Noe AT, Douek N, Donaldson MM, Nji NN, Alvarado GS, Edwards DK, Flebbe DR, Lamb E, Doria-Rose NA, Lin BC, Louder MK, O'Dell S, Schmidt SD, Phung E, Chang LA, Yap C, Todd JM, Pessaint L, Van Ry A, Browne S, Greenhouse J, Putman-Taylor T, Strasbaugh A, Campbell TA, Cook A, Dodson A, Steingrebe K, Shi W, Zhang Y, Abiona OM, Wang L, Pegu A, Yang ES, Leung K, Zhou T, Teng IT, Widge A, Gordon I, Novik L, Gillespie RA, Loomis RJ, Moliva JI, Stewart-Jones G, Himansu S, Kong WP, Nason MC, Morabito KM, Ruckwardt TJ, Ledgerwood JE, Gaudinski MR, Kwong PD, Mascola JR, Carfi A, Lewis MG, Baric RS, McDermott A, Moore IN, Sullivan NJ, Roederer M, Seder RA, Graham BS. Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates. New England Journal Medicine 2020 Jul 28; doi: 10.1056/NEJMoa2024671.
  • Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott A, Flach B, Doria-Rose NA, Corbett KS, Morabito KM, O'Dell S, Schmidt SD, Swanson PA 2nd, Padilla M, Mascola JR, Neuzil KM, Bennett H, Sun W, Peters E, Makowski M, Albert J, Cross K, Buchanan W, Pikaart-Tautges R, Ledgerwood JE, Graham BS, Beigel JH; mRNA-1273 Study Group. An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. New England Journal of Medicine 2020 Jul 14; NEJMoa2022483. doi: 10.1056/NEJMoa2022483.
  • Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020 Feb 19:eabb2507. doi: 10.1126/science.abb2507.
  • Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS. Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nature Immunology 2019 Mar; 20(3):362-372. doi: 10.1038/s41590-018-0305-x.
  • Crank MC, Ruckwardt TJ, Chen M, Morabito KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT, Schwartz RM, Kueltzo L, Cooper JW, Chen P, Stein JA, Carlton K, Gall JG, Nason MC, Kwong PD, Chen GL, Mascola JR, McLellan JS, Ledgerwood JE, Graham BS, and the VRC 317 Study Team. A proof-of-concept for structure-based vaccine design targeting RSV in humans. Science 2019 Aug 2; 365(6452):505-509. doi: 10.1126/science.aav9033.
  • Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proceeding of the National Academy of Sciences USA 2017 Aug 14. pii: 201707304. doi: 10.1073/pnas.1707304114.
  • Dowd KA, Ko SY, Morabito KM, Yang ES, Pelc RS, DeMaso CR, Castilho LR, Abbink P, Boyd M, Nityanandam R, Gordon DN, Gallagher J, Chen XJ, Todd JP, Tsybovsky Y, Harris A, Huang YS, Higgs S, Vanlandingham DL, Andersen H, Lewis MG, De La Barrera R, Eckels KH, Jarman RG, Nason MC, Barouch DH, Roederer M, Kong WP, Mascola JR, Pierson TC, Graham BS. Rapid development of a DNA vaccine for Zika virus. Science 2016; 354(6309):237-240. doi:10.1126/science.aai3197.
  • Kirchdoerfer RN, Cottrell CA, Wang N, Pallesen J, Yassine HM, Turner HL, Corbett KS, Graham BS, McLellan JS, Ward AB. Prefusion structure of a human coronavirus spike protein. Nature 2016 Mar 3; 531(7592):118-21. doi: 10.1038/nature17200.
  • Ngwuta JO, Chen M, Modjarrad K, Joyce MG, Kanekiyo M, Kumar A, Yassine HM, Moin SM, Killikelly AM, Chuang GY, Druz A, Georgiev IS, Rundlet EJ, Sastry M, Stewart-Jones GBE, Yang Y, Zhang B, Nason MC, Capella C, Peeples ME, Ledgerwood JE, McLellan JS, Kwong PD, Graham BS. Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Science Translational Medicine 2015 Oct 14; 7(309):309ra162. doi: 10.1126/scitranslmed.aac4241.
  • Yassine HM, Boyington JC, McTamney PM, Wei CJ, Kanekiyo M, Kong WP, Gallagher JR, Wang LS, Zhang Y, Joyce MG, Lingwood D, Moin SM, Andersen H, Okuno Y, Rao SS, Harris AK, Kwong PD, Mascola JR, Nabel GJ, Graham BS. Hemagglutinin stem nanoparticle generates heterosubtypic influenza protection. Nature Medicine 2015 Sep; 21(9):1065-1070. doi: 10.1038/nm.3927.
  • McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones G, Yang YP, Zhang B, Chen L, Srivatsan S, Zheng A, Zhou T, Graepel KW, Kumar A, Moin S, Boyington JC, Chuang GW, Soto C, Baxa U, Bakker AQ, Spits H, Beaumont T, Zheng ZZ, Xia NS, Ko SY, Todd JP, Rao S, Graham BS, Kwong PD. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science 2013; 342:592-598. doi: 10.1126/science.1243283
  • McLellan JS, Chen M, Leung S, Graepel KW, Du X, Yang Y, Zhou T, Baxa U, Yasuda E, Beaumont T, Kumar A, Modjarrad K, Zheng Z, Zhao M, Xia N, Kwong PD, Graham BS. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 2013; 340:1113-1117.
  • Graham BS, Henderson GS, Tang YW, Lu X, Neuzil KM, Colley DG. Priming immunization determines cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. Journal of Immunology 1993; 151:2032-2040.

Commentaries or Reviews

  • Graham BS. The Journey to RSV Vaccines - Heralding an Era of Structure-Based Design. New England Journal of Medicine 2023 Feb 16; 388(7):579-581. doi: 10.1056/NEJMp2216358.
  • Graham BS. Rapid COVID-19 vaccine development. Science 2020 May 8; eabb8923. doi: 10.1126/science.abb8923.
  • Graham BS, Corbett KS. Prototype pathogen approach for pandemic preparedness: World on fire. Journal of Clinical Investigation 2020 Apr 30:139601. doi: 10.1172/JCI139601.
  • Graham BS, Gilman MSA, McLellan JS. Structure-based vaccine antigen design. Annual Review of Medicine 2019 Jan 27; 70:91-104. doi: 10.1146/annurev-med-121217-094234.
  • Graham BS, Sullivan NJ. Emerging viral diseases from a vaccinology perspective: Preparing for the next pandemic. Nature Immunology 2018 Jan;19(1):20-28. doi: 10.1038/s41590-017-0007-9. Epub 2017 Dec 14.
CLICK HERE to view full list of publications.

Honors and Awards

Election into Honorary Societies

  • 2022 - National Academy of Sciences

 Awards Related to Vaccine Development and Mentoring