Zhigang Xiong, M.D, Ph.D.

Zhigang Xiong, M.D, Ph.D. 



Location: Multidisciplinary Research Center 219
Phone: 404-752-8683
E-mail: zxiong@msm.edu


University of Toronto, School of Medicine
Postdoctoral Fellow

Anhui Medical University
Degree: Doctor of Medicine

University of Ottawa School of Medicine
Doctor of Philosophy in Pharmacology

Research Interests

  • Ion channels
  • Stroke
  • Mechanisms of Neurodegeneration and Neuroprotection


  • Zhou R, Leng T, Yang T, Chen F, Hu W, Xiong ZG. β-estradiol protects against acidosis-mediated and ischemic neuronal injury by promoting ASIC1a (Acid-Sensing Ion Channel 1a) protein degradation. Stroke. 50(10):2902-2911, 2019.
  • Huang Y, Leng TD, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong ZG. TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis. J Biol Chem. 293(37):14393-14406, 2018.
  • Pignataro G, Simon RP, and Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischemia.  Brain. 130(Pt 1): 151-8, 2006
  • Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wemmie JA, Price M, Welsh MJ, and Simon RP.  Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118(6): 687-98, 2004.
  • Xiong ZG, Lu WY and MacDonald JF.  Extracellular calcium sensed by a novel cation channel in hippocampal neurons. Proc. Natl. Acad. Sci. USA, 94:7014-7017, 1997.
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Honors and Awards

  • 2007: Established Investigator Award, American Heart Association
  • 2001: Scientist Development Award, American Heart Association
  • 1998: Centennial Fellowship Award, Medical Research Council of Canada
  • 1996: Postdoctoral Fellowship Award, Medical Research Council of Canada