Hao Anh Duong, Ph.D.
Assistant Professor
Pharmacology & Toxicology
Location: Research Wing D305
Phone: (404) 752-1710
E-mail: hduong@msm.edu
Education
POSTGRADUATE:Harvard Medical School
Neurobiology
GRADUATE:
University of California, Los Angeles, California
Degree: Doctor of Philosophy, Biochemistry/Molecular Genetics
University of California, San Diego, California
Degree: Master of Science, Biochemistry
UNDERGRADUATE:
University of California, San Diego, California
Degree: Bachelor of Science, Chemistry/Biochemistry
Research Interests
The roles of the circadian clock in spatiotemporal integration of biological functions.
Without proper organization of molecular processes cells are just bags of molecules
performing “Brownian” functions. It is the orderly coordination, in time and space,
of molecular events that defines cellular physiology and among physiological processes
that gives rise to tissue functions, which in turn organizes animal behaviors. The
behaviors need be conformed to environmental conditions for the organism’s fitness.
The circadian clock, the endogenous timing system that exists in most cells to help
the organism predicts and responds to changes in environmental conditions, is emerging
as the global temporal organizer, and possibly a spatial organizer, of these processes.
Our laboratory is interested in deciphering these roles of the circadian clock.
Currently, we are studying potential roles of a class of histone methylation enzymes
in the orchestration of daily external environmental cycles and internal physiological
rhythms and its pathological implications. Perturbations of this orchestration, termed
environmental circadian disruption, accelerate the development of multiples metabolic,
cardiovascular and neurodegenerative disorders and cancers such as obesity, arrythmia,
Alzheimer and breast cancer.
Publications
- Tamayo AG, Duong HA, Robles MS, Mann M and Weitz CJ. (2015). Histone mono-ubiquitination by a Clock-Bmal1 complex marks circadian genes for feedback repression. Nature Structural & Molecular Biology. 22(10):759-66.
- Kim JY, Kwak PB, Gebert M, Duong HA and Weitz CJ (2015). Purification and analysis of PERIOD protein complexes of the mammalian circadian clock. Methods in Enzymology 551:197-210.
- Duong HA. and Weitz CJ (2014). Temporal orchestration of repressive chromatin modifiers by mammalian circadian clock PERIOD complexes. Nature Structural & Molecular Biology 21:126-32.
- Duong HA*, Robles MS*, Knutti D and Weitz CJ (2011). A molecular mechanism for circadian clock
negative feedback. Science 332:1436-9. *Equal contribution
- #Editors’ choice. L. B. Ray, Molecular Clockwork. Science Signaling 4, ec176
- #Commented in Faculty of 1000, Kyriacou C: 2011. F1000.com/11539956#eval12586054
- #Commented in Faculty of 1000, Nitabach M: 2011. F1000.com/11916957#eval13031056
- Duong HA, Nagaraj R, Wang CW, Ratnaparkhi G, Sun YH and Courey AJ (2008). Non-cell-autonomous inhibition of photoreceptor development by Dip3. Developmental Biology. 323:105-13
Honors and Awards
- 2014-2015 Mahoney Research Fellow
- 2010 Research Merit Award, Society for Research on Biological Rhythms
- 2008-2010 NRSA Postdoctoral Fellow
- 2006-2007 UCLA Dissertation Research Award, UCLA
- 2005 R&D Wilson Graduate Research Fellow
- 1998 UCSD Summer Research Fellow