Kennie Raviie Shepherd, Ph.D.
Associate Professor
Pharmacology & Toxicology
Location: Research Wing Room 309 & LAB Research Wing Room 327
Phone: 404-756-5732
E-mail: kshepherd@msm.edu
Education
POSTGRADUATE:Emory University
Fellowship: Rollins School of Public Health and Center for Neurodegenerative Disease
St. Jude Children’s’ Research Hospital
Fellowship: Department of Developmental Neurobiology
GRADUATE:
Florida Agricultural and Mechanical University, College of Pharmacy and Pharmaceutical Sciences
Degree: Doctor of Philosophy in Toxicology
UNDERGRADUATE:
Albany State University
Degree: Bachelor of Science in Biology/Science Education
Research Interests
Laboratory of Neurotoxicology/Neuropharmacology
Topics of investigation include:
1). Mechanism(s) of neurotoxicity elicited by pesticides, industrial agents, drugs
of abuse and the Parkinson’s inducing agent 1-methyl-4-phenyl,1,2,3,6-tetrahydropyridine
(MPTP).
2).The role of Genetic and Environmental interactions in neurodegenerative disease:
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after
Alzheimer’s disease. The mean age of onset is 60. PD is a progressive neurodegenerative
disorder characterized by resting tremor, rigidity, slowness in executing body movements
and postural instability, which result from the progressive loss of dopamine (DA)
producing neurons in the substantia nigra. Symptoms appear when 80% of dopamine producing
cells is no longer functioning or lost. To date, there is no cure for PD, and the
cause is unknown. Although the primary cause of PD is unknown, both environmental
and genetic factors are thought to contribute to PD pathogenesis. Pesticide exposure,
rural living, farming, well water drinking, metals, diet, head trauma, and infections
have been proposed as potential risk factors. The lab is interested in how the combination
of exposure to environmental chemicals and altered genetic expression may influence
neurodegeneration as seen in Parkinson’s disease as well as in Alzheimer’s disease.
3). Pathogenesis of neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s
disease as well as other neurological disorders.
4).Molecular, Cellular, and Neurochemical signals controlling neurodegeneration
5). Neuronal Survival, protection and Cell Death
6). Neurochemical and molecular pathways involved in memory, cognition, and depression